| Registro completo |
| Provedor de dados: |
Acta Amazonica
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| País: |
Brazil
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| Título: |
Phenolic compounds from Virola venosa (Myristicaceae) and evaluation of their antioxidant and enzyme inhibition potential
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| Autores: |
FERNANDES,Kamila Rangel Primo
BITTERCOURT,Paulo Senna
SOUZA,Afonso Duarte Leão de
SOUZA,Antonia Queiroz Lima de
SILVA,Felipe Moura Araújo da
LIMA,Emerson Silva
ACHO,Leonard Domingo Rosales
NUNOMURA,Rita de Cássia Saraiva
TEIXEIRA,Ana Frazão
KOOLEN,Hector Henrique Ferreira
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| Data: |
2019-03-01
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| Ano: |
2019
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| Palavras-chave: |
Α-glucosidase inhibition
Antioxidant compounds
Ferulic acid
Amazon
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| Resumo: |
ABSTRACT Virola venosa, popularly known in Brazil as ucuuba-da-mata, occurs naturally in the Amazon region and has potential to provide useful natural compounds, as already known for other Virola species. Therefore, the objective of this study was to determine the chemical composition of bark and leaf extracts of V. venosa, and to test the antioxidant capacity and α-glucosidase inhibition potential of their compounds. Polar extracts showed to be more active in both assays, therefore a bioactivity-guided fractionation was performed to identify the compounds that were responsible for the recorded activities. Using a combination of LC-MS/MS analysis and isolation with NMR identification, eight phenolic compounds were identified. Assays with pure compounds of the active fraction revealed that ferulic acid was the main contributor compound to the observed bioactivity in the crude extracts.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000100048
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| Editor: |
Instituto Nacional de Pesquisas da Amazônia
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| Relação: |
10.1590/1809-4392201800832
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| Formato: |
text/html
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| Fonte: |
Acta Amazonica v.49 n.1 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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