| Registro completo |
| Provedor de dados: |
Acta Amazonica
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| País: |
Brazil
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| Título: |
In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)
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| Autores: |
ARAÚJO,Éverton José Ferreira de
LIMA,Layana Karine Farias
SILVA,Oskar Almeida
JÚNIOR,Luís Mário REZENDE
GUTIERREZ,Stanley Juan Chavez
CARVALHO,Fernando Aécio de Amorim
LIMA,Francisco das Chagas Alves
PESSOA,Cláudia
FREITAS,Rivelilson Mendes de
FERREIRA,Paulo Michel Pinheiro
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| Data: |
2016-09-01
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| Ano: |
2016
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| Palavras-chave: |
Bioprospecting
Chemoprevention
Cytotoxicity
Antiparasitic drug
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| Resumo: |
ABSTRACT Aniba riparia (Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH• (EC50 of 296.2 μg mL-1) and ABTS•+ (EC50 of 450.1 μg mL-1), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 μg mL-1) and leishmanicidal activity on promastigotes of L. amazonensis (IC50 of 307.0 ± 79.6, 193.7 ± 44.3 and 81.8 ± 11.2 μg mL-1, respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000300309
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| Editor: |
Instituto Nacional de Pesquisas da Amazônia
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| Relação: |
10.1590/1809-4392201505436
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| Formato: |
text/html
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| Fonte: |
Acta Amazonica v.46 n.3 2016
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| Direitos: |
info:eu-repo/semantics/openAccess
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