Registro completo |
Provedor de dados: |
Acta Toxicol. Argent.
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País: |
Argentina
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Título: |
Anticoagulant and factor Xa-like activities of Tityus discrepans scorpion venom
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Autores: |
Brazón,Josmary
Guerrero,Belsy
Suze,D
Sevcik, Carlos,Gina
Arocha-Piñango,Carmen L
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Data: |
2013-06-01
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Ano: |
2013
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Palavras-chave: |
Scorpion
Coagulation
Fibrinogen
Factor Xa
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Resumo: |
Tityus discrepans venom (TdV) produces a variety of haemostatic manifestations including alveoli fbrin deposition and/ or prothrombin and partial thromboplastin time (PT, PTT) alterations in mammals. In vitro studies have demonstrated that TdV contains tissue plasminogen activator-like (t-PA), fbrinolytic and plasmin inhibitory compounds and produces platelets activation through GPVI and a novel Src-dependent signalling pathway. The aim of this study is to describe the initial characterization of procoagulant and anticoagulant components from TdV. This venom was fractionated by exclusion molecular chromatography on a Sephadex G-50 column. The eluted material was collected as fve fractions called S1 to S5. These fractions and the whole venom were used to evaluate factor Xa- and thrombin-like activities, fbrinogen degradation, furthermore thrombin- and factor Xa-inhibitory activities. The results demonstrated that TdV contain components with factor Xa-like activity (procoagulants) as well fbrinogenolytic compounds present in the fraction S1 and components with factor Xa inhibitory activity in the fractions S4 and S5 (anticoagulants).
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432013000100003
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Editor: |
Asociación Toxicológica Argentina
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Formato: |
text/html
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Fonte: |
Acta toxicológica argentina v.21 n.1 2013
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Direitos: |
info:eu-repo/semantics/openAccess
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