| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Hypoglycemic property of triterpenoid saponin PFS isolated from Polyscias fruticosa leaves
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| Autores: |
LUYEN,NGUYEN THI
DANG,NGUYEN HAI
BINH,PHUNG THI XUAN
HAI,NGUYEN THI
DAT,NGUYEN TIEN
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| Data: |
2018-09-01
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| Ano: |
2018
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| Palavras-chave: |
Polyscias fruticosa
Araliaceae
Α-amylase
Α-glucosidase
Hypoglycemia
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| Resumo: |
Abstract This paper evaluated the inhibitory effect of 3-O-[β-d-glucopyranosyl-(1→4)-β-d-glucuronopyranosyl] oleanolic acid 28-O-β-d-glucopyranosyl ester (PFS), a major saponin isolated from Polyscias fruticosa leaves, on α-amylase and α-glucosidase, and its potential for reducing the postprandial blood glucose level in mice. In enzyme inhibition assays, PFS strongly inhibited porcine pancreas α-amylase and yeast α-glucosidase. Using the Lineweaver–Burk equation, we found that PFS inhibited porcine pancreas α-amylase in a mixed noncompetitive mode, and yeast α-glucosidase via noncompetitive inhibition. In the sucrose tolerance test, PFS at 100 mg/kg body weight significantly decreased the postprandial blood glucose level in mice fed a high-sucrose diet. These findings suggest that P. fruticosa leaves and their major saponin PFS can be used to prevent and treat diabetes and its complications.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602881
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201820170945
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.90 n.3 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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