| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
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| Autores: |
CHAHOUD,IBRAHIM
PAUMGARTTEM,FRANCISCO J.R.
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| Data: |
2017-05-01
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| Ano: |
2017
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| Palavras-chave: |
Alkylating agents
Embryo development
Phase specificity
Mouse strains
Skeleton anomalies
Teratogenicity
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| Resumo: |
ABSTRACT The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI: GD 9, 91/2 or 10; DBA/2J: GD 10 or 101/2). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar -with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200635
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201720160483
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.89 n.1 suppl.0 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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