| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Biflorin: an o-naphthoquinone of clinical significance
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| Autores: |
WISINTAINER,GABRIELLE G.N.S.
SIMÕES,EVELYNE R.B.
LEMOS,TELMA L.G.
MOURA,SIDNEI
SOUZA,LUCIANA G.S.
FONSECA,ALUISIO M.
MORAES,MANOEL ODORICO
PESSOA,CLAUDIA
ROESCH-ELY,MARIANA
HENRIQUES,JOÃO A.P.
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| Data: |
2014-12-01
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| Ano: |
2014
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| Palavras-chave: |
Biological activity
Biflorin
Capraria biflora
Natural products
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| Resumo: |
Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201420140085
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.86 n.4 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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