| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Silver and gold nanoparticles from tannic acid: synthesis, characterization and evaluation of antileishmanial and cytotoxic activities
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| Autores: |
LOPES,LOURDES C.S.
BRITO,LUCAS M.
BEZERRA,THAYLLAN T.
GOMES,KLEYTON N.
CARVALHO,FERNANDO A. DE A.
CHAVES,MARIANA HELENA
CANTANHÊDE,WELTER
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| Data: |
2018-09-01
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| Ano: |
2018
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| Palavras-chave: |
Green synthesis
Leishmaniasis
Metallic nanoparticles
Tannic acid
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| Resumo: |
Abstract Gold (Au0) and silver (Ag0) nanoparticles were synthesized using tannic acid (TA) as both reducing and stabilizer. Nanoparticles formation, stability, and interaction with TA were compared to citrate-coated nanoparticles and monitored by UV-Vis, zeta potential, and transmission electron microscopy. TA coating resulted in a red-shift and broadening of bands compared to citrate-coated nanoparticles (NPs-Cit). AgNPs-TA and AuNPs-TA are negatively charged with mean surface charge of -29.4 mV and -29.6 mV, respectively. TEM images showed polydispersety of AuNPs-TA (6-42 nm) and aggregation of AgNPs-TA (12-71 nm). In vitro assays of Leishmania amazonensis promastigotes showed an increment of antileishmanial activity for AgNPs-TA in relation to AgNPs-Cit, while AuNPs-TA and AuNPs-Cit did not affect the protozoas at tested concentrations. CC50 value for AgNPs-TA suggested that TA attenuates nanosilver toxicity comparatively to its precursor (Ag+). This investigation can contribute to the development of new, green, and fast produced drugs aiming at leishmaniasis treatment.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602679
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201820170598
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.90 n.3 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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