| Registro completo |
| Provedor de dados: |
Biocell
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| País: |
Argentina
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| Título: |
CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
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| Autores: |
Zhou,Liping
Guo,Xiaolin
Ba,Jing
Zhao,Lianshuang
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| Data: |
2010-08-01
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| Ano: |
2010
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| Palavras-chave: |
Cell migration
Lamellipodia formation
Uropod formation
Hyaluronic acid
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| Resumo: |
CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
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| Tipo: |
Info:eu-repo/semantics/report
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200005
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| Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
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| Formato: |
text/html
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| Fonte: |
Biocell v.34 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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