| Registro completo |
| Provedor de dados: |
Biocell
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| País: |
Argentina
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| Título: |
Ultrastructural effects of two phthalocyanines in CHO-K1 and HeLa cells after laser irradiation
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| Autores: |
de CastroPazos,Marcelo
Pacheco-Soares,Cristina
Soares da Silva,Newton
DaMatta,Renato Augusto
Pacheco,Marcos Tadeu T.
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| Data: |
2003-12-01
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| Ano: |
2003
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| Palavras-chave: |
Photodynamic therapy
Phthalocyanines
Laser
Cell death
Ultrastructure
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| Resumo: |
The effects of Photodynamic Therapy using 2nd generation photosensitizers have been widely investigated aiming clinical application treatment of solid neoplasms. In this work, ultrastructure changes caused by the action of two 2nd generation photosensitizers and laser irradiation on CHO-K1 and HeLa (neoplastic) cells were analyzed by transmission electron microscopy. Aluminum phthalocyanine chloride, aluminum phthalocyanine tetrasulfonate chloride and radiation from a semiconductor laser at a fluency of 0.5 J/cm² (Power=26mW; l=670nm) were used. The results showed induction of apoptosis. Such alterations where observed in HeLa but not in CHO-K1 cells after Aluminum phthalocyanine tetrasulfonate chloride (AlPcS4) photodynamic treatment. The Aluminum phthalocyanine chloride (AlPc) photodynamic treatment induced necrosis on the neoplastic cell line, and cytoplasm and nuclear alterations on the normal cell line.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452003000300001
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| Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
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| Formato: |
text/html
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| Fonte: |
Biocell v.27 n.3 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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