| Registro completo |
| Provedor de dados: |
Biocell
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| País: |
Argentina
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| Título: |
Apoptogenic effect of the lipophilic o-naphthoquinone CG 10-248 on rat hepatocytes: light and electron microscopy studies
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| Autores: |
Lopez,Lidia M.
Dubin,Marta
Carrizo,Patricia H.
Burgos,Mario H.
Pellegrino de Iraldi,Amanda
Stoppani,Andrés O. M.
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| Data: |
2003-08-01
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| Ano: |
2003
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| Palavras-chave: |
Apoptosis
O-naphthoquinones
Hepatocytes
Chromatin Alteration
Mitochondrial Swelling Membrane
Blebs
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| Resumo: |
CG 10-248 (3,4-dihydro-2,2-dimethyl-9-chloro-2H-naphtho[1,2b]pyran- 5,6-dione; CG-NQ), a b-lapachone analogue, modified the ultrastructure of rat hepatocytes, as demonstrated by light and electron microscopy. After 4 h incubation with 100 µM CG-NQ, the following effects were observed: (a) nuclear chromatin condensation; (b) chromatin fragmentation; (c) displacement of mitochondria, concentrated around the nucleus; (d) disruption or expansion of mitochondrial outer or inner membranes, respectively; (e) displacement and alteration of endoplasmic reticulum (rough and smooth); (f) decrease of microvilli; (g) blebbing of plasma membrane and production of apoptotic bodies formed by folding of plasma membrane fragments around mitochondria or peroxysomes; and (h) production of hydrogen peroxide. Expression of such effects varied according to hepatocyte samples and taken together strongly support an apoptotic action of CG-NQ dependent on "reactive oxygen species"
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452003000200007
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| Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
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| Formato: |
text/html
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| Fonte: |
Biocell v.27 n.2 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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