| Registro completo |
| Provedor de dados: |
Biol. Res.
|
| País: |
Chile
|
| Título: |
Iron and glutathione at the crossroad of redox metabolism in neurons
|
| Autores: |
ARACENA,PAULA
AGUIRRE,PABLA
MUÑOZ,PABLO
NÚÑEZ,MARCO T
|
| Data: |
2006-01-01
|
| Ano: |
2006
|
| Palavras-chave: |
Neurons
Iron metabolism
Iron accumulation
Oxidative stress
Glutathione metabolism
Neurodegeneration
|
| Resumo: |
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.
|
| Tipo: |
Journal article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017
|
| Editor: |
Sociedad de Biología de Chile
|
| Formato: |
text/html
|
| Fonte: |
Biological Research v.39 n.1 2006
|
