Registro completo |
Provedor de dados: |
Biol. Res.
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País: |
Chile
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Título: |
Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function
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Autores: |
AVALOS,ANA MARIA
LABRA,CECILIA V.
QUEST,ANDREW F.G.
LEYTON,LISSETTE
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Data: |
2002-01-01
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Ano: |
2002
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Palavras-chave: |
Thy-1 ligand/integrins
GPI-anchored proteins
Strocytes
Focal adhesion
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Resumo: |
Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with ß3 integrin on astrocytes will be discussed. Thy-1 binding to ß3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for ß3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process
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Tipo: |
Journal article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200015
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Editor: |
Sociedad de Biología de Chile
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Formato: |
text/html
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Fonte: |
Biological Research v.35 n.2 2002
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