| Registro completo |
| Provedor de dados: |
Biol. Res.
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| País: |
Chile
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| Título: |
CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
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| Autores: |
Takahashi,Hiroshi
Ikeda,Kazuhiko
Ogawa,Kazuei
Saito,Syunnichi
Ngoma,Alain M
Mashimo,Yumiko
Ueda,Koki
Furukawa,Miki
Shichishima-Nakamura,Akiko
Ohkawara,Hiroshi
Nollet,Kenneth E
Ohto,Hitoshi
Takeishi,Yasuchika
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| Data: |
2015-01-01
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| Ano: |
2015
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| Palavras-chave: |
Regulatory T cells
Allogeneic hematopoietic stem cell transplantation
Thymus
Graft-versus-host disease
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| Resumo: |
BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS: Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041
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| Editor: |
Sociedad de Biología de Chile
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| Formato: |
text/html
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| Fonte: |
Biological Research v.48 2015
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