| Registro completo |
| Provedor de dados: |
Biol. Res.
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| País: |
Chile
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| Título: |
Toll-like Receptors are Key Participants in Innate Immune Responses
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| Autores: |
ARANCIBIA,SERGIO A
BELTRÁN,CAROLL J
AGUIRRE,ISABEL M
SILVA,PAULINA
PERALTA,ALEXIS L
MALINARICH,FRANO
HERMOSO,MARCELA A
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| Data: |
2007-01-01
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| Ano: |
2007
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| Palavras-chave: |
Toll-like receptors
Innate Immunity
Cytokines
MyD88
NFkB
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| Resumo: |
During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001
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| Editor: |
Sociedad de Biología de Chile
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| Formato: |
text/html
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| Fonte: |
Biological Research v.40 n.2 2007
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