| Registro completo |
| Provedor de dados: |
Biol. Res.
|
| País: |
Chile
|
| Título: |
CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
|
| Autores: |
García-Labastida,Laura
Garza-Guajardo,Raquel
Barboza-Quintana,Oralia
Rodríguez-Sanchez,Irám Pablo
Ancer-Rodríguez,Jesús
Flores-Gutierrez,Juan Pablo
Gómez-Macías,Gabriela Sofía
|
| Data: |
2014-01-01
|
| Ano: |
2014
|
| Palavras-chave: |
Breast mucinous carcinoma
Inmunohistochemical
Intestinal differentiation
|
| Resumo: |
BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
|
| Tipo: |
Journal article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100043
|
| Editor: |
Sociedad de Biología de Chile
|
| Formato: |
text/html
|
| Fonte: |
Biological Research v.47 2014
|
