| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)
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| Autores: |
Hughes, Kristelle
Ho, Raimana
Chazaud, Claire
Hermitte, Stéphanie
Greff, Stéphane
Butaud, Jean-françois
Filaire, Edith
Ranouille, Edwige
Berthon, Jean-yves
Raharivelomanana, Phila
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| Data: |
2021-03
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| Ano: |
2021
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| Palavras-chave: |
Fagraea berteroana
Hair growth
Ethnocosmetology
Marquesas islands
Gentianaceae
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| Resumo: |
Fagraea berteroana is a tree used in traditional medicine in various islands of the South Pacific. Here, we studied its hair growth-inducing properties as suggested by one of its Marquesan ethno-uses in haircare. The ethyl acetate extract of the fruits of F. berteroana (FEAE) and four resulting fractions (FEAE-F0, FEAE-F1, FEAE-F2, and FEAE-F3) were tested on hair follicle dermal papilla cells to determine their cell proliferative activity. Furthermore, RT-qPCR analysis enabled gene modulation analysis, while immunostaining of the β-catenin protein was used to follow protein regulation. We found that the plant extracts induced a controlled, dose-dependent cell proliferation. FEAE-F0 simultaneously down-regulated Bone Morphogenetic Protein 2 (BMP2) mRNA expression and upregulated Cyclin-D1 (CCND1) gene expression, which suggests an involvement in the regulation of the Wnt and Transforming Growth Factor beta (TGFβ) pathways that control the hair cycle. FEAE-F0 exhibited a 1.34-fold increase of nuclear β-catenin protein. This is indicative of an active hair growth state. Thus, we conclude that FEAE-F0 could be an innovative candidate in hair care, which opens interesting leads to promote the Marquesan cosmetopoeia.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00678/79021/81426.pdf
https://archimer.ifremer.fr/doc/00678/79021/81427.xlsx
DOI:10.3390/cosmetics8010013
https://archimer.ifremer.fr/doc/00678/79021/
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| Editor: |
MDPI AG
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| Formato: |
application/pdf
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| Fonte: |
Cosmetics (2079-9284) (MDPI AG), 2021-03 , Vol. 8 , N. 1 , P. 13 (14p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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