| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
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| Autores: |
Cosseau, Celine
Wolkenhauer, Olaf
Padalino, Gilda
Geyer, Kathrin K.
Hoffmann, Karl F.
Grunau, Christoph
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| Data: |
2017-04
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| Ano: |
2017
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| Resumo: |
The GxE concept, in which genotype x environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00385/49607/71826.pdf
https://archimer.ifremer.fr/doc/00385/49607/71827.pdf
DOI:10.1016/j.pt.2016.12.002
https://archimer.ifremer.fr/doc/00385/49607/
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| Editor: |
Elsevier Sci Ltd
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| Formato: |
application/pdf
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| Fonte: |
Trends In Parasitology (1471-4922) (Elsevier Sci Ltd), 2017-04 , Vol. 33 , N. 4 , P. 285-294
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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