| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.
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| Autores: |
Longeon, Arlette
Copp, Brent R.
Quevrain, Elodie
Roue, Melanie
Kientz, Betty
Cresteil, Thierry
Petek, Sylvain
Debitus, Cecile
Bourguet-kondracki, Marie-lise
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| Data: |
2011-05
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| Ano: |
2011
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| Palavras-chave: |
Indole derivatives
Bromoindoles
Marine sponge
Rhopaloeides odorabile
Hyrtios sp.
PLA(2) inhibitor
Antioxidant
Cytotoxic
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| Resumo: |
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00214/32485/30975.pdf
DOI:10.3390/md9050879
https://archimer.ifremer.fr/doc/00214/32485/
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| Editor: |
Mdpi Ag
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| Formato: |
application/pdf
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| Fonte: |
Marine Drugs (1660-3397) (Mdpi Ag), 2011-05 , Vol. 9 , N. 5 , P. 879-888
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| Direitos: |
2011 MDPI AG (Basel, Switzerland) unless otherwise stated
info:eu-repo/semantics/openAccess
restricted use
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