| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata
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| Autores: |
Campos, Pierre-eric
Pichon, Emmanuel
Moriou, Céline
Clerc, Patricia
Trépos, Rozenn
Frederich, Michel
De Voogd, Nicole
Hellio, Claire
Gauvin-bialecki, Anne
Al-mourabit, Ali
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| Data: |
2019-03
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| Ano: |
2019
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| Palavras-chave: |
Fascaplysinopsis reticulata
Marine sponge
Tryptamine alkaloids
Antimalarial activity
Antimicrobial activity
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| Resumo: |
Chemical study of the CH2Cl2-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6′-bis-(debromo)-gelliusine F (1), 6-bromo-8,1′-dihydro-isoplysin A (2) and 5,6-dibromo-8,1′-dihydro-isoplysin A (3), along with the synthetically known 8-oxo-tryptamine (4) and the three known molecules from the same family, tryptamine (5), (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their antimicrobial and their antiplasmodial activities. Regarding antimicrobial activities, the best compounds are (2) and (3), with minimum inhibitory concentration (MIC) of 0.01 and 1 µg/mL, respectively, towards Vibrio natrigens, and (5), with MIC values of 1 µg/mL towards Vibrio carchariae. In addition the known 8-oxo-tryptamine (4) and the mixture of the (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7) showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 values of 8.8 and 8.0 µg/mL, respectively
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00485/59664/62722.pdf
https://archimer.ifremer.fr/doc/00485/59664/62723.pdf
DOI:10.3390/md17030167
https://archimer.ifremer.fr/doc/00485/59664/
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| Editor: |
MDPI AG
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| Relação: |
info:eu-repo/grantAgreement/EC/FP7/634674/EU//TASCMAR
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| Formato: |
application/pdf
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| Fonte: |
Marine Drugs (1660-3397) (MDPI AG), 2019-03 , Vol. 17 , N. 3 , P. 167 (10p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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