| Registro completo |
| Provedor de dados: |
ArchiMer
|
| País: |
France
|
| Título: |
Antiviral immunity in marine molluscs
|
| Autores: |
Green, Timothy J.
Raftos, David
Speck, Peter
Montagnani, Caroline
|
| Data: |
2015-09
|
| Ano: |
2015
|
| Resumo: |
Marine molluscs, like all living organisms, are constantly exposed to viruses and have evolved efficient antiviral defences. We review here recent developments in molluscan antiviral immunity against viruses belonging to the order Herpesvirales. Emerging results suggest an interferon-like response and autophagy are involved in the antiviral defence of bivalves to viral infection. Multifunctional plasma proteins from gastropods and bivalves have been identified to have broadspectrum antiviral activity against mammalian viruses. The antiviral defences present in molluscs can be enhanced by genetic selection, as shown by the presence of oyster strains specifically resistant to ostreid herpesvirus type 1. Whether varying amounts or different isofornns of these antiviral plasma proteins contributes to genetic resistance is worthy of further research. Other evolutionarily conserved antiviral mechanisms, such as RNA interference and apoptosis, still need further characterization.
|
| Tipo: |
Text
|
| Idioma: |
Inglês
|
| Identificador: |
http://archimer.ifremer.fr/doc/00296/40743/39736.pdf
DOI:10.1099/jgv.0.000244
http://archimer.ifremer.fr/doc/00296/40743/
|
| Editor: |
Soc General Microbiology
|
| Formato: |
application/pdf
|
| Fonte: |
Journal Of General Virology (0022-1317) (Soc General Microbiology), 2015-09 , Vol. 96 , P. 2471-2482
|
| Direitos: |
2015 The Authors | Published by the Microbiology Society
info:eu-repo/semantics/openAccess
restricted use
|
|
