| Registro completo |
| Provedor de dados: |
ArchiMer
|
| País: |
France
|
| Título: |
Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?
|
| Autores: |
Carvalho, Raquel N.
Arukwe, Augustine
Ait-aissa, Selim
Bado-nilles, Anne
Balzamo, Stefania
Baun, Anders
Belkin, Shimshon
Blaha, Ludek
Brion, Francois
Conti, Daniela
Creusot, Nicolas
Essig, Yona
Ferrero, Valentina E. V.
Flander-putrle, Vesna
Furhacker, Maria
Grillari-voglauer, Regina
Hogstrand, Christer
Jonas, Adam
Kharlyngdoh, Joubert B.
Loos, Robert
Lundebye, Anne-katrine
Modig, Carina
Olsson, Per-erik
Pillai, Smitha
Polak, Natasa
Potalivo, Monica
Sanchez, Wilfried
Schifferli, Andrea
Schirmer, Kristin
Sforzini, Susanna
Sturzenbaum, Stephen R.
Softeland, Liv
Turk, Valentina
Viarengo, Aldo
Werner, Inge
Yagur-kroll, Sharon
Zounkova, Radka
Lettieri, Teresa
|
| Data: |
2014-09
|
| Ano: |
2014
|
| Palavras-chave: |
Bioassays
Effects
Mixtures
Ecotoxicology
Biomarkers
|
| Resumo: |
The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.
|
| Tipo: |
Text
|
| Idioma: |
Inglês
|
| Identificador: |
https://archimer.ifremer.fr/doc/00499/61115/64667.pdf
https://archimer.ifremer.fr/doc/00499/61115/64668.pdf
DOI:10.1093/toxsci/kfu118
https://archimer.ifremer.fr/doc/00499/61115/
|
| Editor: |
Oxford Univ Press
|
| Relação: |
info:eu-repo/grantAgreement/EC/FP7/265721/EU//RADAR
|
| Formato: |
application/pdf
|
| Fonte: |
Toxicological Sciences (1096-6080) (Oxford Univ Press), 2014-09 , Vol. 141 , N. 1 , P. 218-233
|
| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
|
|
