| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Combination vitamin C and vitamin E prevents enteric diabetic neuropathy in the small intestine in rats
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| Autores: |
Zanoni,Jacqueline Nelisis
Hermes-Uliana,Catchia
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| Data: |
2015-08-01
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| Ano: |
2015
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| Palavras-chave: |
Ascorbic acid
Α-tocopherol
Diabetes mellitus
Myenteric plexus
Enteric nervous system
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| Resumo: |
The present study evaluated the effects of supplementation with a combination of vitamin C and vitamin E on NADH-diaphorase-positive (NADH-d+) and neuronal nitric oxide synthase (nNOS)-immunoreactive myenteric neurons in the duodenum and ileum in diabetic rats. Forty rats were distributed into the following groups: normoglycemic (N), normoglycemic supplemented with vitamin C and vitamin E (NS), diabetic (D), and diabetic supplemented with vitamin C and vitamin E (DS). Vitamin C was added to the drinking water, and vitamin E was incorporated in the diet (1%). After 120 days, the animals were euthanized, and the duodenum and ileum were subjected to NADH-d and nNOS staining. Quantitative and morphometric analyses of myenteric neurons were performed. Diabetes reduced NADH-d+ neurons in the D group. The density of nitrergic neurons was not changed by diabetes or vitamin treatment. Hypertrophy of the cell body area of NADH-d+ and nNOS-immunoreactive neurons was observed in both intestinal segments. Combined supplementation with vitamin C and vitamin E prevented the reduction of the density of NADH-d+ neurons and hypertrophy, demonstratred by both techniques. Supplementation with a combination of vitamin C and vitamin E promoted myenteric neuroprotection in the small intestine in diabetic rats.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400504
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-8913201500414
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.58 n.4 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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