| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
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| Autores: |
Andreazza,Itamar Francisco
Ferraz,Humberto Gomes
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| Data: |
2011-04-01
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| Ano: |
2011
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| Palavras-chave: |
Coating
Pellets
Extrusion spheronization
Controlled release
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| Resumo: |
The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132011000200013
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.54 n.2 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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