| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
The Influence of Ca2+ on Gluconeogenesis Stimulation by Glucagon in the Liver of Arthritic Rats
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| Autores: |
Kelmer-Bracht,Ana M.
Fedatto-Júnior,Zélio
Ishii-Iwamoto,Emy L.
Caparroz-Assef,Silvana M.
Bracht,Adelar
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| Data: |
2002-09-01
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| Ano: |
2002
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| Palavras-chave: |
Arthritis
Liver
Gluconeogenesis
Glucagon
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| Resumo: |
Ca2+ participates in the stimulation of hepatic gluconeogenesis by glucagon and there is evidence that Ca2+ fluxes are modified in arthritic rats. These findings raise the question whether hepatic gluconeogenesis in arthritic rats responds differently to glucagon and Ca2+. The experimental system was the isolated perfused rat liver. In the presence of Ca2+, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was equal to that in normal rats in absolute terms, but higher in relative terms (104.5 and 45.2%, respectively). In the absence of Ca2+, however, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was smaller in both absolute and relative terms (18.5 and 41.9%, respectively). It can be concluded that the Ca2+-dependent component of gluconeogenesis activation by glucagon is more important in arthritic than in normal rats.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000300009
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132002000300009
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.45 n.3 2002
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| Direitos: |
info:eu-repo/semantics/openAccess
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