| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Extract of the Bark of Bathysa cuspidataAttenuates the Development of Chemically-Induced Preneoplastic Colorectal Lesions in Rats
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| Autores: |
Rosa,Damiana Diniz
Reis,Sandra Aparecida dos
Siqueira,Nathane Pais
Gonçalves,Reggiani Vilela
Machado,Alessandra Barbosa Ferreira
Tafuri,Natália Filardis
Leite,João Paulo Viana
Matta,Sérgio Luís Pinto da
Peluzio,Maria do Carmo Gouveia
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| Data: |
2015-10-01
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| Ano: |
2015
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| Palavras-chave: |
Bathysa cuspidata
Animal model
Oxidative stress
Aberrant crypt foci
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| Resumo: |
ABSTRACTThe aim of this study was to investigate the effect of the bark extractBathysa cuspidata on chemically induced preneoplastic colorectal lesions in Wistar rats. Forty male rats were randomly divided into four groups (n = 10 each): saline (control group, oral administration of saline solution 0.9%); dimethylsulfoxide (DMSO, vehicle control), B200 (treated with 200 mg/kg bark extract ofB. cuspidata), and B400 (treated with 400 mg/kg bark extract ofB. cuspidata). Administration of treatments was carried out by the gavage. The animals received four subcutaneous injections of 1,2-dimethylhydrazine (DMH, 40 mg/kg) in the initial two weeks of the experiment to induce preneoplastic colorectal lesions. After 15 weeks, the animals were euthanized and the presence of aberrant crypt foci (ACF), body weight, biochemical analyses, and oxidative stress markers were measured. The extract ofB. cuspidata decreased the levels of superoxide dismutase (SOD), but did not influence the levels of catalase (CAT), malondialdehyde (MDA), nitric oxide or protein carbonyl, compared with the saline group. The animals supplemented with a more concentratedB. cuspidata extract (B400) showed a significant reduction in the number of ACF in all the portions of the intestinal mucosa. The study demonstrated that the bark extract ofB. cuspidata at 400 mg/kg reduced the preneoplastic colorectal lesions in an animal model of colon cancer and that the effect could be dose-dependent.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000500732
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132015050228
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.58 n.5 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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