| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Effect of mannitol on the pharmacokinetics of amikacin in wistar rats
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| Autores: |
Olguín,Hugo Juárez
Portugal,Miriam Carrasco
Pérez,Janett Flores
Vieyra,Angélica Camacho
Pérez,Carmen Flores
Rodríguez,Alfonso Alfaro
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| Data: |
2009-08-01
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| Ano: |
2009
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| Palavras-chave: |
Pharmacokinetics
Interactions
Amikacin
Mannitol
Antibiotics
Diuretics
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| Resumo: |
The study analyzed the effect of mannitol on the pharmacokinetics (PK) of amikacin. Adult Wistar rats were treated as follows: Group 1 (G1) received mannitol for three days, Group 2 (G2) received mannitol plus 10 mg/kg of amikacin simultaneously, and Group 3 only amikacin. The PK study was conducted on the 4th day. For which, blood samples were drawn at fixed times during 24 h and immunoenzymatically analyzed. Results revealed significant differences (p<0.05) between the groups, e.g. Cmax were 62.26 ± 15.75 µg/ml for G1, 72.63 ± 24.80 µg/ml for G2 and 68.61 ± 27.40 µg/ml for G3. The AUC also differed in the three groups, being largest for G2, 222.52 ± 47.30 µg/ml/h, and smallest for G1, 135.59 ± 39.00 µg/ml/h. Alteration of the PK parameters observed between the groups must be considered when both drugs are prescribed, although human studies are necessary to confirm the results.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400006
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132009000400006
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.52 n.4 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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