Registro completo |
Provedor de dados: |
BABT
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País: |
Brazil
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Título: |
Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
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Autores: |
Maia Filho,Antonio Luiz Martins
Amaral,Fabrício Pires de Moura do
Martin,Airton Abrahão
Soares,Luís Eduardo Silva
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Data: |
2014-06-01
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Ano: |
2014
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Palavras-chave: |
Bone regeneration
Alumina foams
Apatite coating
FT-Raman spectroscopy
Micronucleus test
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Resumo: |
The aim of this work was to study the influence of uncoated and apatite-coated Al2O3 implants on bone regeneration after 30 days of surgery in New Zealand white rabbits. Twelve samples of Al2O3 implants were prepared and half of them (n = 6) were apatite-coated by the modified biomimetic method. Three experimental groups were tested as Group C - control, surgery procedure without cerami c implant, Group Ce - uncoated Al 2O3 implants (n = 6) and Group CeHA - apatite-coated Al2O3 implants (n = 6). The mineralization of the Al2O3 implants was analyzed in bone fragments using FT-Raman spectroscopy. Raman peaks at 959 cm-1 and 2940 cm-1 evaluated the inorganic and organic bone content, respectively. In vivo citotoxicity was analyzed using micronucleus test. Inorganic and organic content were higher in CeHA samples than in Ce and C (CeHA > Ce > C). FT-Raman spectroscopy showed that the higher the deposition of the organic matrix, more mineralization occurred. The micronucleus test showed that the uncoated and apatite-coated Al2O3 implants were non-cytotoxic and safe to in vivo applications.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300004
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Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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Relação: |
10.1590/S1516-89132014005000002
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Formato: |
text/html
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Fonte: |
Brazilian Archives of Biology and Technology v.57 n.3 2014
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Direitos: |
info:eu-repo/semantics/openAccess
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