| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy
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| Autores: |
Pereira,Kércia Regina Santos Gomes
Açucena,Maria Kadja Meneses Torres
Villarim Neto,Arthur
Rêgo,Amália Cínthia Meneses
Bernardo-Filho,Mário
Azevedo,Ítalo Medeiros
Araújo Filho,Irami
Medeiros,Aldo Cunha
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| Data: |
2008-12-01
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| Ano: |
2008
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| Palavras-chave: |
Splenectomy
Sodium phytate
Biodistribution
Liver
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| Resumo: |
Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132008000700033
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.51 n.spe 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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