| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Influence of tetracycline in the hepatic and renal development of rat's offspring
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| Autores: |
Machado,Ana Lourdes da Silva
Brandão,Adriana Aigotti Haberbeck
Silva,Cláudia Maria de Oliveira Monteiro da
Rocha,Rosilene Fernandes da
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| Data: |
2003-01-01
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| Ano: |
2003
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| Palavras-chave: |
Pregnancy
Development
Tetracycline
Hepatotoxicity
Nephrotoxicity
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| Resumo: |
This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000100008
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132003000100008
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.46 n.1 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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