| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Assessment of bacterial translocation in obstructive jaundice using Tc-99m Escherichia coli
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| Autores: |
Diniz,Simone Odília Fernandes
Barbosa,Alfredo José Afonso
Araújo,Ivana Durval
Nelson,David Lee
Machado,Leonardo Augusto da Silva
Bernardo Filho,Mário
Cardoso,Valbert Nascimento
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| Data: |
2005-10-01
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| Ano: |
2005
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| Palavras-chave: |
Bacterial translocation
Technetium-99m E coli
Obstructive jaundice
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| Resumo: |
In obstructive jaundice, the passage of bacteria and endotoxins through the intestine wall to reach the systemic circulation is associated with septicemia, renal failure and pulmonary dysfunction. The aim of this work was to investigate bacterial translocation utilizing 99mTc-E.coli in an experimental model of obstructive jaundice. The levels of bilirubin in rats that were subjected to ligature of the bile duct were significantly increased when compared to control animals (p < 0.001). The biodistribution results did not show any translocation of 99mTc-E.coli to the mesenteric lymphatic nodules, liver, spleen or lungs of the rats that suffered ligature of the bile duct (p > 0.05). The evaluation of the intestinal permeability using "per os" administration of 99mTc-DTPA showed 1.61 ± 0.57% and 1.39 ± 0.72% of radioactivity in the urine of the control and jaundice animals, respectively. The histological analysis of the distal wall of the ileum showed that the covering epithelium and the crypt were morphologically preserved in both groups. The seven-day period after the ligature of the bile duct may not have been long enough to promote modifications in intestinal wall to occur so as to permit the passage of Tc-99m E.coli.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700006
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132005000700006
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.48 n.spe2 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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