Registro completo |
Provedor de dados: |
BABT
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País: |
Brazil
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Título: |
Down-Regulation of NFkB, Bax,TGF-β, Smad-2mRNA expression in the Livers of Carbon Tetrachloride Treated Rats using Different Natural Antioxidants
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Autores: |
Al-Rasheed,Nouf Mohamed
Fadda,Laila Mohamed
Al-Rasheed,Nawal Mohamed
Ali,Hanaa Mahmoud
Yacoub,Hazar Ibrahim
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Data: |
2016-01-01
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Ano: |
2016
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Palavras-chave: |
CCl4
Silymarin
Chlorogenic acid
Melatonin
MRNA expression
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Resumo: |
The objective of this study is to examine whether silymarin alone or in combination with chlorogenic acid and/ or melatonin plays a modulatory role against apoptotic damage in rats liver induced by of CCl4. The present work revealed that CCl4 induced elevation of in Bax, Smad, TGF-β and NFkBhepatic mRNA expression, administration of silymarin alone down regulates these expressions. Treatment with chlorogenic acid and/ or melatonin along with silymarin produced best results in this concern. Bcl-2 expression was down regulated by CCl4 whereas concurrent treatment of chlorogenic acid and/ or melatonin along with silymarin increased this expression. On conclusion, the use of chlorogenic acid and/ or melatonin potentiates the anti-apoptotic action of silymarin.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100408
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Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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Relação: |
10.1590/1678-4324-2016150553
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Formato: |
text/html
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Fonte: |
Brazilian Archives of Biology and Technology v.59 2016
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Direitos: |
info:eu-repo/semantics/openAccess
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