| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Bioavailability of the sodium pertechnetate and morphometry of organs isolated from rats: study of possible pharmacokinetic interactions of a ginkgo biloba extract
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| Autores: |
Moreno,Silvana Ramos Farias
Carvalho,Jorge José
Nascimento,Ana Lúcia
Pereira,Mário
Rocha,Emely Kazan
Diré,Gláucio
Arnobio,Adriano
Caldas,Luiz Querino de Araújo
Bernardo-Filho,Mario
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| Data: |
2005-10-01
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| Ano: |
2005
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| Palavras-chave: |
Ginkgo biloba extract
Bioavailability
Radiobiocomplex
Sodium pertechnetate
Morphometry
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| Resumo: |
Many compounds affect the bioavailability of radiobiocomplexes as radiopharmaceuticals. Ginkgo Biloba extract (EGb) has several effects. The influence of an EGb on the bioavailability of the radiobiocomplex sodium pertechnetate (Na99mTcO4) and on the morphometry of the organs was evaluated. Rats were treated with EGb and Na99mTcO4 was injected. The animals were sacrificed; the radioactivity in the organs was counted. The results showed that EGb altered the Na99mTcO4 bioavailability in the kidneys, liver and duodenum. Morphometric analysis of the organs showed significant alterations (P<0.05), probably caused by metabolites generated by EGb and capable of altering the bioavailability of the Na99mTcO4.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700011
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132005000700011
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.48 n.spe2 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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