| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study
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| Autores: |
Carvalho Júnior,Álvaro Dutra de
Abrantes,Fabiana Moreira
Menezes,Maria Ângela
Leal,Alexandre Soares
Cardoso,Valbert Nascimento
Oliveira,Mônica Cristina de
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| Data: |
2005-10-01
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| Ano: |
2005
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| Palavras-chave: |
Radiolabelled cisplatin
Biodistribution
TRIGA research reactor
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| Resumo: |
This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700013
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132005000700013
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.48 n.spe2 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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