| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Glucose administration inhibits the hepatic activation of gluconeogenesis promoted by insulin-induced hypoglycemia
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| Autores: |
Galende,Sharize Betoni
Oliveira Neto,Oswaldo Custódio de
Santos,Leandro Freire dos
Peicher,Márcia Vardanega
Souza,Helenir Medri de
Bazotte,Roberto Barbosa
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| Data: |
2009-08-01
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| Ano: |
2009
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| Palavras-chave: |
Hypoglycemia
Glycemia recovery
Hepatic metabolism
Gluconeogenesis
Ureagenesis
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| Resumo: |
The activation of hepatic gluconeogenesis in male Wistar adult 6 h fasted rats during insulin-induced hypoglycemia (IIH) was previously demonstrated. In this study, the effects of intraperitoneal (ip) glucose (100 mg/kg) on the activation of liver gluconeogenesis during IIH was investigated. Thus, 6 h fasted rats that received ip regular insulin (1 U/kg) and 30 min later ip saline (Control group) or glucose (Experimental group) were compared. All the experiments were executed 60 min after insulin injection. The glycemia of Control and Experimental groups were not different (P > 0.05). To investigate gluconeogenesis, liver perfusion experiments were performed. The results demonstrated that excepting glycerol, livers from rats which received ip glucose showed lower (P < 0.05) gluconeogenesis from L-alanine, L-glutamine, L-lactate or L-alanine + L-glutamine + L-lactate + glycerol. Therefore, the absence of glucose recovery after the glucose administration was mediated, at least in part, by an inhibition of hepatic gluconeogenesis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400008
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132009000400008
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.52 n.4 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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