| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
In Vitro study of Vellozia pusilla pohl (Velloziaceae), a Brazilian plant species: antitumoral activity and labeling of blood elements
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| Autores: |
Dantas,Ana Letícia Almeida
Valente,Lígia Maria Marino
Morais,Lilia Aparecida Salgado de
Feliciano,Glaucio
Bernardo-Filho,Mário
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| Data: |
2005-10-01
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| Ano: |
2005
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| Palavras-chave: |
Drug interaction
Antitumoral activity
Technetium-99m
Blood elements
Velloziaceae
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| Resumo: |
Vellozia pusilla Pohl is a species of the botanic family Velloziaceae that occurs in the subtropical regions of South America and, although it lives under conditions of high solar irradiation and low water availability, shows great longevity. The methanol extract of roots, stem and leaf sheaths of this species showed an antitumoral activity through the inhibition of the enzyme Topoisomerase I when analyzed by an in vitro bioassay employing DNA repair or recombination deficient mutants of the yeast Saccharomyces cerevisiae. In the evaluation of the effect of Vellozia pusilla methanol extract on the labeling of RBC, blood of mice was treated with 99mTc tracer solutions. The percentage of radioactivity (%ATI) bound to plasma (P) and blood cells (BC) was determined. The %ATI in the insoluble fraction of plasma (IF) was also evaluate, and the results showed that there was a decrease in %ATI in this fraction that represents the plasmatic proteins.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700008
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132005000700008
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.48 n.spe2 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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