| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers
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| Autores: |
Freitas,Cristina Setim
Baggio,Cristiane Hatsuko
Araújo,Samanta Luiza
Marques,Maria Consuelo Andrade
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| Data: |
2008-08-01
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| Ano: |
2008
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| Palavras-chave: |
Pfaffia glomerata
Crude extract
Healing ulcers
Gastric mucosa
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| Resumo: |
The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000400005
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132008000400005
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.51 n.4 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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