| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Actions of crude hydroalcoholic extract of Pfaffia sp on gastrointestinal tract
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| Autores: |
Freitas,Cristina Setim
Paula,Maria Fernanda Rodrigues de
Rieck,Lia
Marques,Maria Consuelo Andrade
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| Data: |
2003-06-01
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| Ano: |
2003
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| Palavras-chave: |
Pfaffia
Amaranthaceae
Ulcers
Acid secretion
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| Resumo: |
The plants that compound the Pfaffia genus are used in folk medicine to treat gastric disturbances. This study examined the effects of a crude hydroalcoholic extract of Pfaffia sp on the gastrointestinal tract. Female Wistar rats were pretreated orally (p.o.) with the hydroalcoholic extract of Pfaffia (0.5, 1 and 2 g.kg-1) before the induction of ulcer with hypothermic restraint stress (HRS), ethanol (ET) or indomethacin (IND). Control animals received water (C) or ranitidine (60mg/kg) p.o. The hydroalcoholic extract of Pfaffia (0.5, 1 and 2 mg.kg-1) protected rats against HRS and ET - induced ulcers, but was not able to protect the gastric mucosa against IND - induced ulcers. When injected into the duodenal lumen, the hydroalcoholic extract of Pfaffia inhibited basal and stimulated acid secretion in pylorus-ligated rats. These results indicate that this plant has a protective action against gastric lesions of the mucosa involving the reduction of gastric acid secretion.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000300007
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132003000300007
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.46 n.3 2003
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| Direitos: |
info:eu-repo/semantics/openAccess
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