| Registro completo |
| Provedor de dados: |
BABT
|
| País: |
Brazil
|
| Título: |
Antidiabetic Potential of Potentilla fulgens Roots in Validated Animal Models of Diabetes
|
| Autores: |
Pal,Savita
Mishra,Arvind
Rawat,Arun Kumar
Gautam,Sudeep
Maurya,Rakesh
Srivastava,Arvind K.
|
| Data: |
2016-01-01
|
| Ano: |
2016
|
| Palavras-chave: |
Antidiabetic activity
Antihyperglycemic Activity
Antidyslipidemic activity
Potentilla fulgens roots
Alpha (α)-glucosidase enzyme
|
| Resumo: |
The present study was undertaken to investigate the antidiabetic potential of tap roots of Potentilla fulgens in streptozotocin induced diabetic rat models. The crude powder, ethanolic, ethanolic: aqueous and aqueous extracts of tap roots were administered to normoglycemic- and streptozotocin (STZ)-induced diabetic rats in a single dose study. The ethanolic extract showed significant improvement in oral glucose tolerance and antihyperglycemic effect on sucrose loaded normal rats and STZ-induced diabetic rats. Of the isolated aqueous, n-butanol, chloroform and n-hexane soluble fractions of the active ethanolic extract of the roots, the aqueous fraction (100 mg/kg body weight) showed significant blood glucose lowering effect on STZ-induced diabetic rats. In a multiple dose study, aqueous fraction of ethanolic extract of P. fulgens roots significantly improved the body weight, percent glycated hemoglobin (%HbA1c), fasting blood glucose, oral glucose tolerance (OGTT), serum insulin, lipid profile, liver and kidney parameters in STZ-induced diabetic rats. The aqueous fraction also showed marked improvement in OGTT and serum insulin level in neonatal STZ-induced diabetic rats for 30 consecutive days. The aqueous fraction of the roots also inhibited the activity of alpha (α)-glucosidase enzyme in a dose dependent manner. In conclusion, the finding suggested that an aqueous fraction of tap roots of P. fulgens possessed potential antidiabetic activity.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100318
|
| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
|
| Relação: |
10.1590/1678-4324-2016150259
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Archives of Biology and Technology v.59 2016
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
|
