| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Evaluation of different adjuvants formulations for bluetongue vaccine
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| Autores: |
Macedo,Ludmila Branco
Lobato,Zélia Inês Portela
Fialho,Sílvia Ligório
Viott,Aline de Marco
Guedes,Roberto Maurício Carvalho
Silva-Cunha,Armando
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| Data: |
2013-12-01
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| Ano: |
2013
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| Palavras-chave: |
Emulsion
Microemulsion
Vaccine adjuvants
Immunology
Biocompatibility
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| Resumo: |
This study investigated the adjuvant potential of W/O/W multiple emulsions and microemulsions, comparing them with traditional aluminum hydroxide and oil-in-water emulsion adjuvants against bluetongue vaccine (BTV). Local inflammatory reactions were assessed in rabbits by measuring the temperature of the animals and the skin thickness at the site of application. Antibodies titers were determined by serum-neutralization test. Histological analyses of lesions at the site of adjuvants application were done. Results showed that multiple emulsion and microemulsion maintained their stability even in the presence of complex components and presented adequate characteristics for subcutaneous administration. They were able to induce immune response against BTV, but it was smaller than the traditional adjuvants. Despite microemulsion adjuvant showed lower antibodies titre, it was easier to prepare more stable at 4°C and it was the only one that did not induce any local reaction.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000600007
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132013005000002
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.56 n.6 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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