| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients
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| Autores: |
Passos,Ana Isabela Morsch
Dertkigil,Rachel Polo
Ramos,Marcelo de Carvalho
Busso-Lopes,Ariane Fidelis
Tararan,Cibele
Ribeiro,Erivan Olinda
Schreiber,Angélica Zaninelli
Trabasso,Plinio
Resende,Mariangela Ribeiro
Moretti,Maria Luiza
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| Data: |
2017-12-01
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| Ano: |
2017
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| Palavras-chave: |
Pulmonary infection
HIV/AIDS
(1-3)-β-D-Glugan
LDH
LAMP
Pneumocystosis
Fungal infection
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| Resumo: |
ABSTRACT Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients’ serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600606
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2017.07.002
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.21 n.6 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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