Registro completo |
Provedor de dados: |
BJID
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País: |
Brazil
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Título: |
Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis and delay in starting antiretroviral therapy for AIDS patients
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Autores: |
Brites,C
Goyanna,F
França,LG
Pedroso,C
Netto,EM
Adriano,S
Sampaio,J
Harrington Jr,W
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Data: |
2011-02-01
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Ano: |
2011
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Palavras-chave: |
HIV
HTLV-I/II
Coinfection Strongyloidiasis
CD4/CD8
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Resumo: |
OBJECTIVE: To compare the clinical characteristics and outcomes of HIV-1-HTLV-1 coinfected patients, in Bahia, Brazil. METHODS: Retrospective, comparative study. RESULTS: Among a total of 123 consecutive HIV infected patients, 20 men (20.6%) and 6 women (23.1%) had detectable antibodies against HTLV-I/II. The major risk factor associated with coinfection by HTLV was intravenous drug use (57.7% of coinfected patient versus 9.2% of HTLV seronegative patients, p < 0.0001). Coinfected patients had higher absolute lymphocyte counts (1,921 + 762 versus 1,587 + 951, p = 0.03). Both groups of patients had similar means of CD4+ and CD8+ cell counts. However, among patients with AIDS CD4+ cell counts were significantly higher among those coinfected with HTLV-I/II (292 ± 92 cells/mm³, versus 140 ± 177cells/mm³, p = 0.36). The frequency and type of opportunistic infections were similar for both groups, but strongyloidiasis and encephalopathy were more frequently diagnosed in coinfected patients (p < 0.05). On the other hand, patients coinfected with HTLV-I/II received significantly less antiretroviral therapy than singly infected by HIV-1. CONCLUSION: Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis for HIV patients. Higher CD4 count may lead to underestimation of immunodeficiency, and delay to initiate antiretroviral therapy.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100002
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Editor: |
Brazilian Society of Infectious Diseases
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Relação: |
10.1590/S1413-86702011000100002
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Infectious Diseases v.15 n.1 2011
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Direitos: |
info:eu-repo/semantics/openAccess
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