| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Occult hepatitis B virus infection in immunocompromised patients
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| Autores: |
Jardim,Ruth Nogueira Cordeiro Moraes
Gonçales,Neiva Sellan Lopes
Pereira,Josiane Silveira Felix
Fais,Viviane Cristina
Gonçales Junior,Fernando Lopes
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| Data: |
2008-08-01
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| Ano: |
2008
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| Palavras-chave: |
Occult HBV infection
HBV-DNA
Anti-HBc alone
Hemodialysis
HIV
Immunosupressed patients
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| Resumo: |
Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702008000400008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.12 n.4 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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