| Registro completo |
| Provedor de dados: |
BJID
|
| País: |
Brazil
|
| Título: |
Metabolic profile and cardiovascular risk factors among Latin American HIV-infected patients receiving HAART
|
| Autores: |
Cahn,P
Leite,O
Rosales,A
Cabello,R
Alvarez,CA
Seas,C
Carcamo,C
Cure-Bolt,N
L'Italien,Gp
Mantilla,P
Deibis,L
Zala,C
Suffert,T
|
| Data: |
2010-04-01
|
| Ano: |
2010
|
| Palavras-chave: |
HAART
HIV
Metabolic parameters
Cardiovascular risk factors
Metabolic syndrome
Dyslipidemia
|
| Resumo: |
OBJECTIVE: Determine the prevalence of metabolic abnormalities (MA) and estimate the 10-year risk for cardiovascular disease (CVD) among Latin American HIV-infected patients receiving highly active anti-retroviral therapy (HAART). METHODS: A cohort study to evaluate MA and treatment practices to reduce CVD has been conducted in seven Latin American countries. Adult HIV-infected patients with at least one month of HAART were enrolled. Baseline data are presented in this analysis. RESULTS: A total of 4,010 patients were enrolled. Mean age (SD) was 41.9 (10) years; median duration of HAART was 35 (IQR: 10-51) months, 44% received protease inhibitors. The prevalence of dyslipidemia and metabolic syndrome was 80.2% and 20.2%, respectively. The overall 10-year risk of CVD, as measured by the Framingham risk score (FRF), was 10.4 (24.7). Longer exposure to HAART was documented in patients with dyslipidemia, metabolic syndrome and type 2 diabetes mellitus. The FRF score increased with duration of HAART. Male patients had more dyslipidemia, high blood pressure, smoking habit and higher 10-year CVD than females. CONCLUSIONS: Traditional risk factors for CVD are prevalent in this setting leading to intermediate 10-year risk of CVD. Modification of these risk factors through education and intervention programs are needed to reduce CVD.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200008
|
| Editor: |
Brazilian Society of Infectious Diseases
|
| Relação: |
10.1590/S1413-86702010000200008
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Infectious Diseases v.14 n.2 2010
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
|
