| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil
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| Autores: |
Queiroz,Artur Trancoso Lopo de
Santos,Luciane Amorim
Moreau,Domingos Ramon
Oliveira,Tulio de
Watkins,David I.
Galvão-Castro,Bernardo
Alcantara,Luiz Carlos Junior
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| Data: |
2007-02-01
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| Ano: |
2007
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| Palavras-chave: |
HIV-1
Env
Vaccine
Epitope
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| Resumo: |
Genetic analysis of HIV-1 is essential to improve treatment strategies and select epitopes for vaccine programs. The objective of this study was to determine whether known CD4+ and CD8+ epitopes were present in Brazilian HIV-1 strains. We used previously described CD8+ and CD4+ epitopes from the Los Alamos laboratory to search for these epitopes in the Brazilian sequences using the HIVbase program and we compared the frequency results with the analyses using physical-chemical profile tools from Network Protein Sequence Analysis (NPSA), and the SYFPEITHI program. Furthermore, this analysis was carried out with the Prosite tool using the GeneDoc program and ds/dn analyses using the Synonymous Nonsynonymous Analysis Program (SNAP). The HIVbase epitope mapping demonstrated that 30 CD8+ and 6 CD4+ epitopes were present in the Brazilian sequences at a high frequency. Only two of these epitopes were heavily glycosylated. Interestingly, ds/dn analyses showed evidence of purifying selective pressure. These types of analyses could be useful for the assessment of possible vaccine efficiency in populations.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100008
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702007000100008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.11 n.1 2007
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| Direitos: |
info:eu-repo/semantics/openAccess
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