| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil
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| Autores: |
Barroso,David Eduardo
Carvalho,DM
Casagrande,ST
Rebelo,MC
Soares,V
Zahner,V
Solari,CA
Nogueira,SA
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Neisseria meningitidis
Meningococcal disease
Epidemic
Meningitis
Sepsis
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| Resumo: |
The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a significant shift in the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and early management of suspected cases.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300008
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1590/S1413-86702010000300008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.14 n.3 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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