Registro completo |
Provedor de dados: |
BJMBR
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País: |
Brazil
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Título: |
Interleukin-15 as a potential regulator of the innate immune response
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Autores: |
Carson,W.
Caligiuri,M.A.
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Data: |
1998-01-01
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Ano: |
1998
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Palavras-chave: |
Interleukin-15
Interleukin-12
Gamma interferon
Natural killer cell
Innate immunity
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Resumo: |
Interleukin-15 (IL-15) is a newly-discovered cytokine that is produced by activated monocytes early in the course of the innate immune response. IL-15 is able to bind to components of the interleukin-2 receptor (IL-2R) despite the fact that it has no sequence homology with IL-2. IL-15 stimulates human natural killer cell proliferation, cytotoxicity, and cytokine production and can substitute for IL-2 under most conditions. In vitro studies indicate that monocyte-derived IL-15 may be an important determinant of IFN-gamma production by NK cells. In addition, IL-15 is able to promote the survival of natural killer cells under serum-free conditions. The IL-15 receptor is a heterotrimeric complex which is composed of the IL-2Rß and <FONT FACE="Symbol">g</font> chains in combination with a unique alpha chain (IL-15<FONT FACE="Symbol">a</font>). The IL-15R<FONT FACE="Symbol">a</font> chain has strong sequence homology to the IL-2R<FONT FACE="Symbol">a</font> chain and confers high affinity binding to the IL-15R. In contrast to IL-2, transcript for IL-15 and IL-15<FONT FACE="Symbol">a</font> is expressed in a number of tissues and indicates that IL-15 may be an important ligand for cells that express components of the IL-2R
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100001
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Editor: |
Associação Brasileira de Divulgação Científica
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Relação: |
10.1590/S0100-879X1998000100001
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Medical and Biological Research v.31 n.1 1998
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Direitos: |
info:eu-repo/semantics/openAccess
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