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Provedor de dados:  BJMBR
País:  Brazil
Título:  Cystatin C and renal function in pediatric kidney transplant recipients
Autores:  Franco,M.C.P.
Nagasako,S.S.
Machado,P.G.
Nogueira,P.C.K.
Pestana,J.O.M.
Sesso,R.
Data:  2009-12-01
Ano:  2009
Palavras-chave:  Children
Kidney transplant
Cystatin C
Creatinine
Glomerular filtration rate
Resumo:  In clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function. We compared GFR estimated by plasma cystatin C with GFR estimated by serum creatinine in a sample of 50 pediatric renal transplant recipients and 24 healthy children. The correlation between GFR estimated by serum creatinine and by cystatin C was significant (r = 0.75; P < 0.001, Person’s correlation); however, in pediatric kidney transplant recipients, the GFR was 6.7 mL/min lower when determined using cystatin C rather than serum creatinine. Moreover, using GFR estimated by cystatin C we found that 42% of the pediatric kidney transplant recipients had an estimated GFR <60 mL·min-1·1.73 (m²)-1, whereas when GFR was estimated by the serum creatinine formula only 16% of the children had values below this cutoff point indicative of chronic kidney disease (P < 0.001). We conclude that, in pediatric kidney transplant recipients, estimation of GFR yields lower values when cystatin C is used rather than serum creatinine.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200017
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2009007500003
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.42 n.12 2009
Direitos:  info:eu-repo/semantics/openAccess
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