| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
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| Autores: |
DosReis,G.A.
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| Data: |
2011-02-01
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| Ano: |
2011
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| Palavras-chave: |
Trypanosoma cruzi
T cells
GPI-anchors
TGF-β
Mucin
Apoptosis
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| Resumo: |
Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2011007500005
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.44 n.2 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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