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Provedor de dados:  BJMBR
País:  Brazil
Título:  Residence of liquids in the infra-junctional portion of the proximal stomach in patients with gastroesophageal reflux disease
Autores:  Barbieri,C.L.A.
Troncon,L.E.A.
Herculano Jr.,J.R.L.
Aprile,L.R.O.
Dantas,R.O.
Data:  2005-09-01
Ano:  2005
Palavras-chave:  Gastroesophageal reflux disease
Gastric emptying
Gastric motility
Intragastric distribution
Proximal stomach
Resumo:  Patients with gastroesophageal reflux disease may have disturbances of gastric motility, which could play a role in the pathophysiology of the disease. Recent studies have suggested that the gastric region just below the gastroesophageal junction may have a distinct physiological behavior. We determined whether patients with gastroesophageal reflux disease have abnormal residence of food in the infra-junctional portion of the stomach after ingesting a liquid nutrient meal. Fasted adult patients with reflux disease (N = 11) and healthy volunteers (N = 10) ingested a liquid meal (320 ml; 437 kcal) labeled with 99m technetium-phytate and their total gastric emptying half-time and regional emptying from the stomach infra-junctional region were determined. In 8 patients, episodes of postprandial acidic reflux to the esophagus were measured for 2 h using pH monitoring. There were no differences between reflux patients and controls regarding total gastric emptying time (median: 68 min; range: 39-123 min vs 65 min and 60-99 min, respectively; P > 0.50). Food residence in the infra-junctional area was similar for patients and controls: 23% (range: 20-30) vs 27% (range: 19-30%; P = 0.28) and emptying from this area paralleled total gastric emptying (Rs = 0.79; P = 0.04). There was no correlation between residence of food in the infra-junctional area and episodes of gastroesophageal reflux (Rs = 0.06; P = 0.88). We conclude that it is unlikely that regional motor disturbances involving the infra-junctional region of the stomach play a relevant role in the pathogenesis of acidic gastroesophageal reflux.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900012
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X2005000900012
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.38 n.9 2005
Direitos:  info:eu-repo/semantics/openAccess
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