| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations
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| Autores: |
Teixeira,D.
Vargens,D.
Príncipe,A.
Oliveira,E.
Amorim,A.
Prata,M.J.
Suarez-Kurtz,G.
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| Data: |
2010-07-01
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| Ano: |
2010
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| Palavras-chave: |
African populations
GSTM3 polymorphisms
Multidimensional scaling analysis
Pharmacogenetics
Population diversity
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| Resumo: |
A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3 *A/*B polymorphism.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700010
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2010007500056
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.43 n.7 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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